Discovery of New Treatment to Overcome Resistance to Steroids in Severe Asthma Patients

October 25, 2013 · Filed Under Trendy Products · Comments Off on Discovery of New Treatment to Overcome Resistance to Steroids in Severe Asthma Patients 

RIKEN New TreatmentResearchers from the RIKEN Center for Integrative Medical Sciences and Keio University in Japan has are working on a new treatment that can be used to overcome resistance to steroids in severe asthma patients. A type of lymphocytes called natural helper (NH) cells plays a critical role in corticosteroid resistance. According to the study by the researchers at both institutes the anti-psychotic drug Pimozide can be used to overcome resistance to steroids in severe asthma patients. T lymphocytes and NH cells in asthmatic lung produce proteins named interleukin (IL)-5 and IL-13 responsible for severe airway inflammation. In asthma patients, inhaled steroids function by suppressing both T lymphocytes and NH cells. However, in severe asthma patients another protein called interleukin-33 (IL-33) is produced in the airways which strongly activate NH cells to produce IL-5 and IL-13, causing a severe airway inflammation. Read more

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